Sparse Notes Re Dopamine, Brain, & Gastrointestinal Tract

 

Many drugs that improve swallowing or can induce or exacerbate swallowing difficulties are related to dopamine metabolism (source)

Nausea and vomiting can result from dopamine receptors within the gut interacting with Parkinson's treatments, such as levodopa, that are intended to act upon dopamine receptors in the brain.Jul 6, 2021 (source)

Dopamine receptors are primarily found in the mesenteric, coronary, cerebral, gastric, and hepatic vasculature. (source)

Oral administration of levodopa alone results in the rapid peripheral conversion of levodopa to dopamine which decreases the desired therapeutic effect and causes significant GI side effects such as nausea and vomiting. (source)

Many studies have shown that dopamine receptors are widely distributed in the gastrointestinal tract and dopamine regulates the gastrointestinal tract function on the movement, secretion, and gastric mucosal blood flow (source)